Approximately half of the patients with temporal arthritis have a clinical syndrome of polymyalgia rheumatica that may even be the only manifestation of the disease, moreover, recent studies have found histological signs of arthritis in the biopsy of the temporal artery in up to 15% of patients with polymyalgia rheumatica without cephalic symptoms of vasculitis and need the Diabetes Pin.

Within the differential diagnosis of polymyalgia rheumatica for presenting similar clinical findings are neoplastic diseases such as gastric or renal cell carcinoma, acute and chronic infections such as miliary tuberculosis or endocarditis, depression, thyroid disorders, cervical spondylosis, amyloidosis, myeloma, leukemia, osteomyelitis, fibromyalgia, rheumatoid arthritis and polymyositis.

The clinical history, the physical examination and the laboratory data help us to distinguish these diseases from polymyalgia rheumatica. Pharmacological therapy includes first of all the use of the Diabetes Pin and corticosteroids whose response is excellent and the use of anti-inflammatories is not recommended.

Management of musculoskeletal pain in the elderly

Pain management strategies in the elderly have not been evaluated systematically and most are based on clinical experience in young adults or patients with cancer pain, although between 60 and 80% of those over 60 years refer pain of musculoskeletal origin, especially the elderly living in residences and long-stay centers.

In the elderly the pain appears more easily, since each and every one of its different organs and appliances have suffered losses in the The course of aging and defensive systems are limited. The differential diagnosis requires a more complex assessment and the same applies to its treatment and Diabetes Pin.

Aging generates pharmacodynamic and pharmacokinetic changes that require changes to such decisive points as the selection of the ideal drug, its doses, the intervals between them or the duration of follow-up. The main consequence is that the study of pain in the elderly requires dedication, special knowledge and being informed about the aging process and the specific peculiarities of the painful conditions that affect the elderly necessitating the use of the Diabetes Pin.

In the elderly most physiological processes they are altered, as, for example, the absorption can have a delay due to the decrease of the intestinal perfusion, the distribution of the drugs changes, when changing with the age the corporal composition, the loss of the muscular mass and the corporal water total, with increased fat. Water-soluble drugs have a smaller volume of distribution, with higher concentrations and fat-soluble drugs are widely distributed, causing a delayed elimination.

The decrease in hepatic mass can increase the concentration of the active substance of those drugs with a large metabolism first step, and prolong the serum half-life of drugs metabolized by the liver. Renal elimination of many drugs decreases with both age and certain diseases.